Linked Life Data

21789020

Source:http://linkedlifedata.com/resource/pubmed/id/21789020

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-7-26
pubmed:abstractText
Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs) form a protein complex with aminoacyl-tRNA synthetases. In addition to protein translation, AIMPs play a role in diverse biological processes. Earlier studies suggested that AIMPs may act as tumor suppressors. However, the expression status of the AIMP proteins in human cancer tissues is largely unknown. In this study, we analyzed the expression of AIMP members (AIMP1, AIMP2 and AIMP3) in gastric cancer (GC) and colorectal cancer (CRC) tissues. We analyzed the expression of these proteins in 100 GC and 103 CRC tissues by immunohistochemistry using a tissue microarray method. Normal gastric and colon mucosa expressed AIMP1, AIMP2 and AIMP3 in nearly all of the cases (95-100%). However, the expression of AIMP1, AIMP2 and AIMP3 was significantly decreased in the GC samples (60%, 52% and 70% of the cases, respectively) and in the CRC samples (66%, 53% and 81% of the cases, respectively) ( P <0.01). Expression of AIMP1, AIMP2 or AIMP3 was not associated with clinicopathological parameters including differentiation, depth of invasion and TNM stage. The decreased expression of AIMP1, AIMP2 and AIMP3 in the GC and CRC tissues compared to the corresponding normal tissues suggested that downregulation of these proteins may be related to inactivation of the tumor suppressor functions of AIMP proteins and might play a role in the development of GC and CRC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8916
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
380-5
pubmed:meshHeading
pubmed-meshheading:21789020-Amino Acyl-tRNA Synthetases, pubmed-meshheading:21789020-Colorectal Neoplasms, pubmed-meshheading:21789020-Cytokines, pubmed-meshheading:21789020-Down-Regulation, pubmed-meshheading:21789020-Gastric Mucosa, pubmed-meshheading:21789020-Gene Expression Regulation, Neoplastic, pubmed-meshheading:21789020-Humans, pubmed-meshheading:21789020-Immunohistochemistry, pubmed-meshheading:21789020-Intestinal Mucosa, pubmed-meshheading:21789020-Neoplasm Proteins, pubmed-meshheading:21789020-Peptide Elongation Factors, pubmed-meshheading:21789020-Protein Array Analysis, pubmed-meshheading:21789020-RNA-Binding Proteins, pubmed-meshheading:21789020-Stomach Neoplasms, pubmed-meshheading:21789020-Tissue Scaffolds, pubmed-meshheading:21789020-Tumor Markers, Biological, pubmed-meshheading:21789020-Tumor Suppressor Proteins
pubmed:articleTitle
Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase complex, is downregulated in gastric and colorectal cancer.
pubmed:affiliation
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't