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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-8-31
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pubmed:abstractText |
The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rhodopsin,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Inhibitory Amino Acid...,
http://linkedlifedata.com/resource/pubmed/chemical/Viaat protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/channelrhodopsin 2, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate decarboxylase 1,
http://linkedlifedata.com/resource/pubmed/chemical/yellow fluorescent protein, Bacteria
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1546-1726
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1118-20
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pubmed:meshHeading |
pubmed-meshheading:21785436-Action Potentials,
pubmed-meshheading:21785436-Animals,
pubmed-meshheading:21785436-Bacterial Proteins,
pubmed-meshheading:21785436-Brain Mapping,
pubmed-meshheading:21785436-Electroencephalography,
pubmed-meshheading:21785436-Electromyography,
pubmed-meshheading:21785436-Evoked Potentials, Somatosensory,
pubmed-meshheading:21785436-Glutamate Decarboxylase,
pubmed-meshheading:21785436-Imaging, Three-Dimensional,
pubmed-meshheading:21785436-Light,
pubmed-meshheading:21785436-Luminescent Proteins,
pubmed-meshheading:21785436-Mice,
pubmed-meshheading:21785436-Mice, Inbred C57BL,
pubmed-meshheading:21785436-Mice, Transgenic,
pubmed-meshheading:21785436-Microscopy, Confocal,
pubmed-meshheading:21785436-Neural Pathways,
pubmed-meshheading:21785436-Neurons,
pubmed-meshheading:21785436-Optical Devices,
pubmed-meshheading:21785436-Patch-Clamp Techniques,
pubmed-meshheading:21785436-Rhodopsin,
pubmed-meshheading:21785436-Somatosensory Cortex,
pubmed-meshheading:21785436-Thalamic Nuclei,
pubmed-meshheading:21785436-Vesicular Inhibitory Amino Acid Transport Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles.
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pubmed:affiliation |
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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