Linked Life Data

21784019

Source:http://linkedlifedata.com/resource/pubmed/id/21784019

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-7-25
pubmed:abstractText
Several species of invertebrates have been studied to examine the toxicological effects of chemicals that include insecticides and heavy metals. We characterized heat-shock protein (hsp) genes from the ubiquitous midge, Chironomidae. More than 70 fold induction of hsp70 expression was detected by quantitative PCR after 37°C treatment in the midge. Expression of hsp70 was induced not only by heat but also by exposure to insecticides and heavy metals such as cadmium and copper. Expression time courses for hsp70 were highly specific to each chemical. When midges were exposed to sub-lethal level of a pyrethroid insecticide, ethofenprox, hsp70 expression was increased over 20 fold with a transient peak at 1.5h. Heavy metal exposure led to delayed hsp70 up regulation of 7 fold at 6-7h. Expression of another hsp70-cognate gene (hsc70) was also characterized. Using these genes we propose a novel system for biomonitoring of heavy metals and other pollutants.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Sep
pubmed:issn
1872-7077
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-301
pubmed:year
2009
pubmed:articleTitle
Induction profile of HSP70-cognate genes by environmental pollutants in Chironomidae.
pubmed:affiliation
Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan. vzz05106@nifty.com
pubmed:publicationType
Journal Article