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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
|
pubmed:dateCreated |
1991-3-14
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pubmed:abstractText |
Ten 2- to 4-month-old rabbits were inoculated subcutaneously with bovine leukemia virus (BLV)-infected bovine or sheep cells. By 6 weeks after inoculation all ten rabbits had converted to BLV antibody-positive, and BLV or BLV antigen was detected in lymphocytes from most of the rabbits tested, although there were few antigen-producing cells. Three rabbits showed continuous respiratory symptoms after infection and one died with pneumonia. Humoral immune responses against mouse serum were significantly suppressed in BLV-infected rabbits compared with non-infected control rabbits. The lymphocyte blastogenesis response was also suppressed in BLV-infected rabbits. At the time of necropsy, six rabbits showed pulmonary lesions; however, none of the BLV-infected rabbits had tumors during an observation period of over 1 year.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0378-1135
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-41
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2177933-Animals,
pubmed-meshheading:2177933-Antibodies, Viral,
pubmed-meshheading:2177933-Antigens, Viral,
pubmed-meshheading:2177933-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2177933-Fluorescent Antibody Technique,
pubmed-meshheading:2177933-Giant Cells,
pubmed-meshheading:2177933-Immunity, Cellular,
pubmed-meshheading:2177933-Leukemia, Experimental,
pubmed-meshheading:2177933-Leukemia Virus, Bovine,
pubmed-meshheading:2177933-Lung,
pubmed-meshheading:2177933-Lymphocyte Activation,
pubmed-meshheading:2177933-Rabbits
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pubmed:year |
1990
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pubmed:articleTitle |
Suppression of immunological responses in rabbits experimentally infected with bovine leukemia virus.
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pubmed:affiliation |
Department of Veterinary Microbiology, Rakuno Gakuen University, Ebetsu, Japan.
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pubmed:publicationType |
Journal Article
|