|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2011-7-22
|
|
pubmed:abstractText |
Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations. We investigated regulation of IL-15 induction by rhinovirus in human macrophages in vitro, IL-15 levels in bronchoalveolar lavage (BAL) fluid and IL-15 induction by rhinovirus in BAL macrophages from asthmatic and control subjects, and related these to outcomes of infection in vivo. Rhinovirus induced IL-15 in macrophages was replication-, NF-?B- and ?/? interferon-dependent. BAL macrophage IL-15 induction by rhinovirus was impaired in asthmatics and inversely related to lower respiratory symptom severity during experimental rhinovirus infection. IL-15 levels in BAL fluid were also decreased in asthmatics and inversely related with airway hyperresponsiveness and with virus load during in vivo rhinovirus infection. Deficient IL-15 production in asthma may be important in the pathogenesis of asthma exacerbations.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-10233906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-10510389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-11244049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-11466332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-11591195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-11742275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-11897281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-11923551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-11972599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-12070282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-12162875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-14607946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-15286001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-15533438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-15699120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-15781584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-15972637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-16873280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-16906156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-17158609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-17239392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-18303999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-18768794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-18950657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-19729181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-19815859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-20336062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-7767192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-8675621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-9601937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21779162-9637536
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1553-7374
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e1002114
|
|
pubmed:meshHeading |
pubmed-meshheading:21779162-Asthma,
pubmed-meshheading:21779162-Female,
pubmed-meshheading:21779162-HeLa Cells,
pubmed-meshheading:21779162-Humans,
pubmed-meshheading:21779162-Interferon-alpha,
pubmed-meshheading:21779162-Interferon-beta,
pubmed-meshheading:21779162-Interleukin-15,
pubmed-meshheading:21779162-Macrophages, Alveolar,
pubmed-meshheading:21779162-Male,
pubmed-meshheading:21779162-NF-kappa B,
pubmed-meshheading:21779162-Picornaviridae Infections,
pubmed-meshheading:21779162-Rhinovirus,
pubmed-meshheading:21779162-Viral Load
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations.
|
|
pubmed:affiliation |
Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
