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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-8-10
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pubmed:abstractText |
Here we report an oral alkylphospholipid perifosine dramatically sensitizes chemo-resistant ovarian cancer cells to paclitaxel induced cell death and apoptosis in vitro. We found that co-administration perifosine with paclitaxel in human ovarian cancer cells led to the inhibition of AKT/mTOR complex 1 (mTORC1), a marked increase in ceramide and reactive oxygen species (ROS) production, and a striking increase in the activation of pro-apoptosis pathways, including caspase 3, c-Jun N-terminal kinases (JNK) and AMP-activated protein kinase (AMPK). These signaling events together caused a marked increase of cancer cell apoptosis. Combining paclitaxel with perifosine may represent a novel anti-ovarian cancer strategy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AMP-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Ceramides,
http://linkedlifedata.com/resource/pubmed/chemical/D 21266,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PRKAA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1872-7980
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
310
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
118-28
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pubmed:meshHeading |
pubmed-meshheading:21775054-AMP-Activated Protein Kinases,
pubmed-meshheading:21775054-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:21775054-Apoptosis,
pubmed-meshheading:21775054-Blotting, Western,
pubmed-meshheading:21775054-Caspase 3,
pubmed-meshheading:21775054-Cell Line, Tumor,
pubmed-meshheading:21775054-Cell Survival,
pubmed-meshheading:21775054-Ceramides,
pubmed-meshheading:21775054-Drug Synergism,
pubmed-meshheading:21775054-Female,
pubmed-meshheading:21775054-HT29 Cells,
pubmed-meshheading:21775054-Humans,
pubmed-meshheading:21775054-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:21775054-Ovarian Neoplasms,
pubmed-meshheading:21775054-Paclitaxel,
pubmed-meshheading:21775054-Phosphorylcholine,
pubmed-meshheading:21775054-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21775054-RNA Interference,
pubmed-meshheading:21775054-Reactive Oxygen Species,
pubmed-meshheading:21775054-Signal Transduction,
pubmed-meshheading:21775054-TOR Serine-Threonine Kinases
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pubmed:year |
2011
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pubmed:articleTitle |
Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition.
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pubmed:affiliation |
Central Lab., Jining First People's Hospital, 6 Jiankang Road, Jining City, Shandong Province 272111, PR China.
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pubmed:publicationType |
Journal Article
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