Linked Life Data

2177497

Source:http://linkedlifedata.com/resource/pubmed/id/2177497

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-3-7
pubmed:abstractText
In heart transplantation, accelerated graft arteriosclerosis leading to late postoperative graft failure is still an unsolved problem, and its pathogenesis is poorly understood. The existence of multiple underlying mechanisms has been discussed without conclusive results. In kidney transplantation, a negative influence of cytomegalovirus infection on long-term graft function and patient survival could be demonstrated. To evaluate the role of this infection on the incidence of coronary artery disease in the transplanted heart, we have analyzed the cytomegalovirus serostatus in 38 long-term survivors of orthotopic heart transplantation. In 14 patients (group A) graft arteriosclerosis was diagnosed by means of coronary angiography. In 24 patients (group B) the coronary vessels showed no pathologic findings. In 10 patients (71%) of group A serologic study showed evidence of cytomegalovirus infection, whereas only five patients (24%) of group B revealed cytomegalovirus infection. In two further patients of this group herpes zoster infection occurred (p less than 0.0001). Cytomegalovirus infection seems to be an important factor in the development of accelerated graft arteriosclerosis in the transplanted heart.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0887-2570
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
707-11
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Role of cytomegalovirus infection in the development of coronary artery disease in the transplanted heart.
pubmed:affiliation
Department of Surgery, German Heart Institute Berlin, F.R.G.
pubmed:publicationType
Journal Article, Comparative Study