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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-2-25
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pubmed:abstractText |
Protein kinase C activation in human platelets has a modulatory role in maintaining intracellular pH (pHi), by adjusting pHi at a particular value (7.22). Changes in pHi induced by protein kinase C appeared to be dependent upon the difference between H+ efflux catalyzed by the Na+/H+ exchanger and H+ production. The pHi recovery after acid loading was significantly facilitated by protein kinase C activation. Analysis of the rate constant for pHi recovery suggested that the turnover rate or the apparent affinity of the Na+/H+ exchanger for H+ was increased. Protein kinase C also decreased the Km value of the Na+/H+ exchanger for extracellular Na+. Thus, it is suggested that the role of protein kinase C in platelet pHi regulation is dual, adjusting the pHi value at a certain setpoint on the one hand, and increasing the rate constant of the Na+/H+ exchanger on the other.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0340-6245
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-71
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2177231-Acids,
pubmed-meshheading:2177231-Blood Platelets,
pubmed-meshheading:2177231-Carrier Proteins,
pubmed-meshheading:2177231-Cytoplasm,
pubmed-meshheading:2177231-Diglycerides,
pubmed-meshheading:2177231-Enzyme Activation,
pubmed-meshheading:2177231-Humans,
pubmed-meshheading:2177231-Hydrogen-Ion Concentration,
pubmed-meshheading:2177231-Kinetics,
pubmed-meshheading:2177231-Propionic Acids,
pubmed-meshheading:2177231-Protein Kinase C,
pubmed-meshheading:2177231-Sodium-Hydrogen Antiporter
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pubmed:year |
1990
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pubmed:articleTitle |
Modification of Na+/H+ exchanger in human platelets by 1,2-dioctanoylglycerol, a protein kinase C activator.
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pubmed:affiliation |
Department of Clinical and Laboratory Medicine, Yamanashi Medical College, Japan.
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pubmed:publicationType |
Journal Article
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