Linked Life Data

2177189

Source:http://linkedlifedata.com/resource/pubmed/id/2177189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-2-28
pubmed:abstractText
The effects of ethanol administration on binding characteristics of the highly selective mu and delta opioid receptor agonists 8H-[D-Ala2-MePhe4-Gly5-ol]enkephalin (3H-DAGO) and 3H-[D-Pen2, D-Pen5] enkephalin (3H-DPDPE), respectively, were investigated in the rat brain. Chronic but not acute ethanol administration profoundly increased affinity of 3H-DPDPE without changing the number of delta receptors. Stress, applied before each ethanol administration, prevents the above changes. On the other hand, chronic treatment with ethanol did not affect the binding characteristics of 3H-DAGO. These results suggest particular sensitivity of the delta opioid receptor to chronic ethanol administration. Furthermore, a possible involvement of endogenous opioid peptide systems in the enhancement of delta opioid receptor sensitivity is postulated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0244
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-42
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Stress prevents the chronic ethanol-induced delta opiod receptor supersensitivity in the rat brain.
pubmed:affiliation
Department of Neuropeptides Research, Polish Academy of Sciences, Kraków, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't