Linked Life Data

2177095

Source:http://linkedlifedata.com/resource/pubmed/id/2177095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-2-27
pubmed:abstractText
Primary bovine fibroblasts derived from foetal palate can be transformed by bovine papillomavirus type 4 DNA only in the presence of an activated ras gene, indicating that the virus does not encode all the information required for morphological transformation of non-established cells. A subgenomic fragment containing the complete E8 and E7 open reading frames (ORFs) induces transformation in cooperation with activated ras but transformation is abolished when the E7 ORF is deleted at the 3' end, showing that this ORF encodes a necessary transforming function. Transformation is more aggressive when the E8 and E7 ORFs are placed under the transcriptional control of the long terminal repeat of the mouse Moloney leukaemia virus, suggesting that the degree of transformation is dependent on the level of expression of these genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1317
pubmed:author
pubmed:issnType
Print
pubmed:volume
71 ( Pt 12)
pubmed:geneSymbol
ras
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3041-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cooperation between bovine papillomavirus type 4 and ras in the morphological transformation of primary bovine fibroblasts.
pubmed:affiliation
Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Glasgow, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't