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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1991-2-25
|
| pubmed:abstractText |
Herpesvirus type 1 could be propagated most efficiently in cultured fetal neurons, to a lesser extent in NG108-15 neurohybridoma cells, and with the lowest titer in glial cells. Herpesvirus type 2 could not be cultured in neurohybridoma cells, and in fetal neurons a titer 100-fold lower than for herpesvirus type 1 was obtained. Cells infected with herpesvirus type 1 were used in an infectivity assay for acyclovir dose-response studies. The ED50 values were 7.4 nmol/l for fetal neurons, 180 for neurohybridoma cells, and 275 nmol/l for glial cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-5526
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
285-9
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2177046-Acyclovir,
pubmed-meshheading:2177046-Animals,
pubmed-meshheading:2177046-Cells, Cultured,
pubmed-meshheading:2177046-Cytopathogenic Effect, Viral,
pubmed-meshheading:2177046-Hybridomas,
pubmed-meshheading:2177046-Mice,
pubmed-meshheading:2177046-Neuroglia,
pubmed-meshheading:2177046-Neurons,
pubmed-meshheading:2177046-Simplexvirus,
pubmed-meshheading:2177046-Spinal Cord,
pubmed-meshheading:2177046-Virus Cultivation
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Effect of acyclovir on herpes simplex virus infected neuronal, glial, and neurohybridoma cells in vitro.
|
| pubmed:affiliation |
Deutsche Wellcome GmbH, Burgwedel, FRG.
|
| pubmed:publicationType |
Journal Article
|