Linked Life Data

2177020

Source:http://linkedlifedata.com/resource/pubmed/id/2177020

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-2-28
pubmed:abstractText
Time courses of effects of lidocaine on sodium currents and sodium dependent action potentials were studied in somata of small and large neurons. Cultured rat sensory spinal ganglion cells (diameter: 30 microns) and neurons of the buccal ganglion of Helix pomatia (diameter: 150 microns) served as the test cells. The latency of the suppressive action of lidocaine was the longer the larger the of the cells was. Maximal blocking effects occurred within 10 min in sensory spinal ganglion cells and within 40 min in snail neurons. Model calculations based on the assumptions (i) that lidocaine is distributed in the extra- and intracellular space by simple diffusion and (ii) that the drug concentration at the outer surface of the cells is elevated stepwisely, revealed a strong dependency of intracellular concentration changes on the size of the cells. From these findings it is concluded that lidocaine blocks sodium channels primarily from the intracellular side.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0231-5882
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Time courses of lidocaine effects on sodium membrane currents in small and large neurons.
pubmed:affiliation
Institute of Physiology, University of Essen, FRG.
pubmed:publicationType
Journal Article, In Vitro