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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-8-9
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pubmed:abstractText |
The molecular mechanism by which catecholaminergic polymorphic ventricular tachycardia is induced by single amino acid mutations within the cardiac ryanodine receptor (RyR2) remains elusive. In the present study, we investigated mutation-induced conformational defects of RyR2 using a knockin mouse model expressing the human catecholaminergic polymorphic ventricular tachycardia-associated RyR2 mutant (S2246L; serine to leucine mutation at the residue 2246).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:DoiMasahiroM,
pubmed-author:FukudaMasakazuM,
pubmed-author:HinoAkihiroA,
pubmed-author:IkedaYasuhiroY,
pubmed-author:IkemotoNoriakiN,
pubmed-author:KobayashiShigekiS,
pubmed-author:MatsuzakiMasunoriM,
pubmed-author:OkudaShinichiS,
pubmed-author:OnoMakotoM,
pubmed-author:SuetomiTakeshiT,
pubmed-author:TateishiHirokiH,
pubmed-author:UchinoumiHitoshiH,
pubmed-author:XuXiaojuanX,
pubmed-author:YamamotoTakeshiT,
pubmed-author:YanoMasafumiM
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
682-94
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pubmed:meshHeading |
pubmed-meshheading:21768539-Allosteric Site,
pubmed-meshheading:21768539-Amino Acid Sequence,
pubmed-meshheading:21768539-Amino Acid Substitution,
pubmed-meshheading:21768539-Animals,
pubmed-meshheading:21768539-Calcium,
pubmed-meshheading:21768539-Dantrolene,
pubmed-meshheading:21768539-Diastole,
pubmed-meshheading:21768539-Epinephrine,
pubmed-meshheading:21768539-Gene Knock-In Techniques,
pubmed-meshheading:21768539-Humans,
pubmed-meshheading:21768539-Ion Channel Gating,
pubmed-meshheading:21768539-Mice,
pubmed-meshheading:21768539-Mice, Transgenic,
pubmed-meshheading:21768539-Models, Cardiovascular,
pubmed-meshheading:21768539-Molecular Sequence Data,
pubmed-meshheading:21768539-Muscle Relaxants, Central,
pubmed-meshheading:21768539-Mutation, Missense,
pubmed-meshheading:21768539-Myocytes, Cardiac,
pubmed-meshheading:21768539-Peptide Fragments,
pubmed-meshheading:21768539-Point Mutation,
pubmed-meshheading:21768539-Protein Conformation,
pubmed-meshheading:21768539-Protein Structure, Tertiary,
pubmed-meshheading:21768539-Recombinant Fusion Proteins,
pubmed-meshheading:21768539-Running,
pubmed-meshheading:21768539-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:21768539-Tachycardia, Ventricular
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pubmed:year |
2011
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pubmed:articleTitle |
Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²?release leading to catecholaminergic polymorphic ventricular tachycardia.
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pubmed:affiliation |
Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, Yamaguchi, 755-8505, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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