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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2011-7-18
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pubmed:abstractText |
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1549-5477
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pubmed:author |
pubmed-author:BanerjiShantanuS,
pubmed-author:BarretinaJordiJ,
pubmed-author:BronsonRoderick TRT,
pubmed-author:ChiangDerek YDY,
pubmed-author:CrowleyDeniseD,
pubmed-author:DaytonTalya LTL,
pubmed-author:DooleyAlison LAL,
pubmed-author:GarrawayLeviL,
pubmed-author:JacksTylerT,
pubmed-author:MeyersonMatthewM,
pubmed-author:SennaStephanieS,
pubmed-author:SnyderEric LEL,
pubmed-author:StranskyNicolasN,
pubmed-author:WhittakerCharles ACA,
pubmed-author:WinslowMonte MMM
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1470-5
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pubmed:dateRevised |
2011-9-14
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pubmed:meshHeading |
pubmed-meshheading:21764851-Animals,
pubmed-meshheading:21764851-Animals, Genetically Modified,
pubmed-meshheading:21764851-Apoptosis,
pubmed-meshheading:21764851-Cell Line, Tumor,
pubmed-meshheading:21764851-Cell Proliferation,
pubmed-meshheading:21764851-Cell Survival,
pubmed-meshheading:21764851-Cell Transformation, Neoplastic,
pubmed-meshheading:21764851-Disease Models, Animal,
pubmed-meshheading:21764851-Gene Expression Profiling,
pubmed-meshheading:21764851-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21764851-Humans,
pubmed-meshheading:21764851-Mice,
pubmed-meshheading:21764851-NFI Transcription Factors,
pubmed-meshheading:21764851-Oncogenes,
pubmed-meshheading:21764851-Small Cell Lung Carcinoma
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pubmed:year |
2011
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pubmed:articleTitle |
Nuclear factor I/B is an oncogene in small cell lung cancer.
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pubmed:affiliation |
David H. Koch Institute for Integrative Cancer Research,Department of Biology, Massachusetts Institute of Technology, Cambridge, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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