Linked Life Data

21762452

Source:http://linkedlifedata.com/resource/pubmed/id/21762452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2011-9-8
pubmed:abstractText
Temporal lobe epilepsy (TLE) is one of the most common forms of human epilepsy and is characterized by spontaneous recurrent seizures and cognitive deficits, often accompanied by hippocampal damage. Mutations in genes encoding for voltage-gated sodium channels have been shown to result in seizure disorders in humans. As a genetic model of TLE, we studied transgenic mice harboring a missense mutation of the sodium channel Scn2a (Nav1.2). In these mice, called Q54, spontaneous recurrent limbic motor seizures began at around 2 months of age and were accompanied by hippocampal sclerosis. We tested whether an enriched sensorimotor experience from birth (environmental enrichment) is effective in counteracting development of hyperexcitability and histopathologic changes in Q54 mice. We found that enriched Q54 animals displayed a dampened frequency of epileptic discharges and reduced hippocampal damage. Therefore, environmental enrichment from birth reduces spontaneous seizures and neuronal damage in the Q54 model of TLE.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1528-1167
pubmed:author
pubmed:copyrightInfo
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
pubmed:issnType
Electronic
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e113-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Environmental enrichment reduces spontaneous seizures in the Q54 transgenic mouse model of temporal lobe epilepsy.
pubmed:affiliation
Neurobiology Laboratory, Scuola Normale Superiore, Pisa, Italy.
pubmed:publicationType
Journal Article