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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-7-29
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pubmed:abstractText |
Declined lung function is a risk factor for particulate matter associated respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD). Carbon nanoparticles (CNP) are a prominent component of outdoor air pollution that causes pulmonary toxicity mainly through inflammation. Recently we demonstrated that mice (C3H/HeJ) with higher than normal pulmonary function resolved the elicited pulmonary inflammation following CNP exposure through activation of defense and homeostasis maintenance pathways. To test whether CNP-induced inflammation is affected by declined lung function, we exposed JF1/Msf (JF1) mice with lower than normal pulmonary function to CNP and studied the pulmonary inflammation and its resolution.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21756372-10601190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21756372-11679793,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 Ganguly et al; licensee BioMed Central Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
94
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pubmed:meshHeading |
pubmed-meshheading:21756372-Animals,
pubmed-meshheading:21756372-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:21756372-Carbon,
pubmed-meshheading:21756372-Disease Models, Animal,
pubmed-meshheading:21756372-Female,
pubmed-meshheading:21756372-Inflammation Mediators,
pubmed-meshheading:21756372-Lung,
pubmed-meshheading:21756372-Lymphocytes,
pubmed-meshheading:21756372-Macrophages,
pubmed-meshheading:21756372-Mice,
pubmed-meshheading:21756372-Nanoparticles,
pubmed-meshheading:21756372-Neutrophil Infiltration,
pubmed-meshheading:21756372-Neutrophils,
pubmed-meshheading:21756372-Pneumonia,
pubmed-meshheading:21756372-Proteins,
pubmed-meshheading:21756372-Proteomics,
pubmed-meshheading:21756372-Time Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation.
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pubmed:affiliation |
Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg/Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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