|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2011-7-28
|
|
pubmed:abstractText |
Focal segmental glomerulosclerosis is a kidney disease that is manifested as the nephrotic syndrome. It is often resistant to glucocorticoid therapy and progresses to end-stage renal disease in 50 to 70% of patients. Genetic studies have shown that familial focal segmental glomerulosclerosis is a disease of the podocytes, which are major components of the glomerular filtration barrier. However, the molecular cause in over half the cases of primary focal segmental glomerulosclerosis is unknown, and effective treatments have been elusive.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1533-4406
|
|
pubmed:author |
pubmed-author:AbbateIsabellaI,
pubmed-author:BenigniArielaA,
pubmed-author:BettoniSerenaS,
pubmed-author:BuelliSimonaS,
pubmed-author:CalabriaAndreaA,
pubmed-author:CapobianchiMaria RosariaMR,
pubmed-author:CassisPaolaP,
pubmed-author:DelledonneMassimoM,
pubmed-author:DonadelliRobertaR,
pubmed-author:EmreSevincS,
pubmed-author:HildebrandtFriedhelmF,
pubmed-author:IatropoulosParaskevasP,
pubmed-author:IbsirliogluTulinT,
pubmed-author:KrendelMiraM,
pubmed-author:MacciardiFabioF,
pubmed-author:MarantaRamonaR,
pubmed-author:MeleCaterinaC,
pubmed-author:MorigiMarinaM,
pubmed-author:NorisMarinaM,
pubmed-author:OttoEdgarE,
pubmed-author:OzaltinFatihF,
pubmed-author:PecoraroCarmineC,
pubmed-author:PirasRossellaR,
pubmed-author:PodoNet Consortium,
pubmed-author:RemuzziGiuseppeG,
pubmed-author:SchaeferFranzF,
pubmed-author:TomasoniSusannaS
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
28
|
|
pubmed:volume |
365
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
295-306
|
|
pubmed:meshHeading |
pubmed-meshheading:21756023-Age of Onset,
pubmed-meshheading:21756023-Animals,
pubmed-meshheading:21756023-Child,
pubmed-meshheading:21756023-Child, Preschool,
pubmed-meshheading:21756023-Drug Resistance,
pubmed-meshheading:21756023-Female,
pubmed-meshheading:21756023-Genes, Recessive,
pubmed-meshheading:21756023-Genetic Linkage,
pubmed-meshheading:21756023-Genome-Wide Association Study,
pubmed-meshheading:21756023-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:21756023-Glucocorticoids,
pubmed-meshheading:21756023-Humans,
pubmed-meshheading:21756023-Infant,
pubmed-meshheading:21756023-Kidney Glomerulus,
pubmed-meshheading:21756023-Male,
pubmed-meshheading:21756023-Mice,
pubmed-meshheading:21756023-Microscopy, Fluorescence,
pubmed-meshheading:21756023-Mutation,
pubmed-meshheading:21756023-Mutation, Missense,
pubmed-meshheading:21756023-Myosin Type I,
pubmed-meshheading:21756023-Pedigree,
pubmed-meshheading:21756023-Podocytes,
pubmed-meshheading:21756023-Sequence Alignment
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
MYO1E mutations and childhood familial focal segmental glomerulosclerosis.
|
|
pubmed:affiliation |
Mario Negri Institute for Pharmacological Research, Clinical Research Center for Rare Diseases, Aldo e Cele Daccò Ranica, Bergamo, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
