Source:http://linkedlifedata.com/resource/pubmed/id/21753698
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2011-7-14
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| pubmed:abstractText |
?? T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic ?? T-cell lymphoma (HSTL) and primary cutaneous ?? T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also be involved and whether they represent a spectrum of the same disease are not well studied. The lack of T-cell receptor (TCR)? expression has been used to infer a ?? origin when other methods are not available. We studied 35 T-cell tumors suspected to be ?? TCL using monoclonal antibodies reactive with TCR ? or ? in paraffin sections. We were able to confirm ?? chain expression in 22 of 35 cases. We identified 8 PCGD-TCLs, 6 HSTLs, and 8 ?? TCLs without hepatosplenic or cutaneous involvement involving mainly extranodal sites. Two such cases were classified as enteropathy-associated T-cell lymphoma, type II. The other ?? TCL presented in the intestine, lung, tongue, orbit, and lymph node. In addition, we observed 13 cases with mainly extranodal involvement that lacked any TCR expression ("TCR silent"). In all cases, a natural killer cell origin was excluded. In conclusion, the lack of TCR? expression does not always predict ??-T-cell derivation, as TCR silent cases may be found. The recognition of ?? TCL presenting in extranodal sites other than skin and liver/spleen expands the clinical spectrum of these tumors. However, non-HSTL ?? TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1532-0979
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| pubmed:author |
pubmed-author:AlvaroTomasT,
pubmed-author:ArrunateguiAna MariaAM,
pubmed-author:ChuangShih-SungSS,
pubmed-author:ColomerDolorsD,
pubmed-author:ColomoLuisL,
pubmed-author:EstrachTeresaT,
pubmed-author:FernandezEvaE,
pubmed-author:Garcia-HerreraAdrianaA,
pubmed-author:GaulardPhilippeP,
pubmed-author:GonzalvoElenaE,
pubmed-author:JaffeElaine SES,
pubmed-author:KochM FMF,
pubmed-author:MartinezAntonioA,
pubmed-author:PittalugaStefaniaS,
pubmed-author:RaffeldMarkM,
pubmed-author:RozmanMariaM,
pubmed-author:SongJoo YJY,
pubmed-author:VillamorNeusN,
pubmed-author:de Anda GonzalezJazminJ
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1214-25
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| pubmed:meshHeading |
pubmed-meshheading:21753698-Adolescent,
pubmed-meshheading:21753698-Adult,
pubmed-meshheading:21753698-Aged,
pubmed-meshheading:21753698-Female,
pubmed-meshheading:21753698-Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor,
pubmed-meshheading:21753698-Genes, T-Cell Receptor gamma,
pubmed-meshheading:21753698-Humans,
pubmed-meshheading:21753698-Immunohistochemistry,
pubmed-meshheading:21753698-Immunophenotyping,
pubmed-meshheading:21753698-In Situ Hybridization,
pubmed-meshheading:21753698-Lymphoma, T-Cell,
pubmed-meshheading:21753698-Lymphoma, T-Cell, Cutaneous,
pubmed-meshheading:21753698-Male,
pubmed-meshheading:21753698-Middle Aged,
pubmed-meshheading:21753698-Paraffin Embedding,
pubmed-meshheading:21753698-Polymerase Chain Reaction,
pubmed-meshheading:21753698-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:21753698-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:21753698-Skin Neoplasms,
pubmed-meshheading:21753698-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:21753698-Young Adult
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Nonhepatosplenic ?? T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation.
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| pubmed:affiliation |
Department of Pathology, Hospital Clinic, IDIBAPS, Barcelona, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
|