Linked Life Data

21749449

Source:http://linkedlifedata.com/resource/pubmed/id/21749449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-7-13
pubmed:abstractText
Early prefibrotic myelofibrosis (early PMF) is a diagnosis that clinically and histologically mimic essential thrombocythemia (ET), but is important to distinguish from ET, polycythemia vera (PV) and primary myelofibrosis (PMF) due to its different prognosis and clinical evolution. In this study, we assessed the allele burden of JAK2V617F in bone marrow biopsies from patients with these chronic myeloproliferative neoplasms. We correlated our findings with the amount of phosphorylated STAT3 (P-STAT3) and STAT5 (P-STAT5) in megakaryocyte nuclei in the bone marrow. The JAK2V617F allele burden was significantly higher in patients with PV (median: 50.99, range: 23.08-97.29, p < 0.01 and p < 0.01) and PMF (median: 44.13, range: 33.61-92.17, p < 0.05 and p < 0.01) compared with a low allele burden in ET (median: 23.465, range: 8.67-47.92) and early PMF (median: 25.68, range: 0.61-49.13) respectively. In addition, we found a significantly higher phosphorylation of STAT5 and STAT3 in the JAK2V617F positive group than in the negative group. There was no positive correlation between increasing JAK2V617F allele burden and the amount of P-STAT3 and P-STAT5. However, we found low values of P-STAT5 in bone marrow biopsies from patients with ETJAK2V617F+ as compared with patients with early PMFJAK2V617F+. Although this difference was statistically significant, larger studies are needed to firmly support this conclusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1600-0463
pubmed:author
pubmed:copyrightInfo
© 2011 The Authors. APMIS © 2011 APMIS.
pubmed:issnType
Electronic
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
498-504
pubmed:dateRevised
2011-10-30
pubmed:meshHeading
pubmed-meshheading:21749449-Alleles, pubmed-meshheading:21749449-Biopsy, pubmed-meshheading:21749449-Bone Marrow Neoplasms, pubmed-meshheading:21749449-Cross-Sectional Studies, pubmed-meshheading:21749449-DNA, pubmed-meshheading:21749449-Humans, pubmed-meshheading:21749449-Immunohistochemistry, pubmed-meshheading:21749449-Janus Kinase 2, pubmed-meshheading:21749449-Phosphorylation, pubmed-meshheading:21749449-Polycythemia Vera, pubmed-meshheading:21749449-Polymorphism, Single Nucleotide, pubmed-meshheading:21749449-Primary Myelofibrosis, pubmed-meshheading:21749449-Retrospective Studies, pubmed-meshheading:21749449-STAT3 Transcription Factor, pubmed-meshheading:21749449-STAT5 Transcription Factor, pubmed-meshheading:21749449-Statistics, Nonparametric, pubmed-meshheading:21749449-Thrombocythemia, Essential
pubmed:year
2011
pubmed:articleTitle
The JAK2V617F allele burden and STAT3- and STAT5 phosphorylation in myeloproliferative neoplasms: early prefibrotic myelofibrosis compared with essential thrombocythemia, polycythemia vera and myelofibrosis.
pubmed:affiliation
Department of Hematology, Roskilde Hospital, Denmark. malene.risum@gmail.com
pubmed:publicationType
Journal Article, Comparative Study