Source:http://linkedlifedata.com/resource/pubmed/id/21745000
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2011-7-12
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| pubmed:abstractText |
CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy. The aim of the study was to investigate CD147 expression in non-small cell lung cancer (NSCLC), and evaluate its correlation with cisplatin-based chemotherapy resistance. In this study, we examined immunohistochemically the expression of CD147 in 118 advanced NSCLC cases treated with cisplatin-based chemotherapy, and then the association of CD147 expression with clinicopathological characteristics was analyzed. Furthermore, RNA interference approach was used to silence CD147 expression in a cisplatin-resistant human lung cancer cell line A549/DDP, and the inhibition effect of cisplatin on tumor cells was assayed by MTT. In the overall series, positive CD147 expression was observed in 101/118 (85.6%) cases. A membranous CD147 pattern was identified in 76/101 (75.2%) of CD147 positive tumors. CD147 membranous expression,but not the overall CD147 expression, was associated with poor response to cisplatin-based chemotherapies and a poor prognosis in advanced NSCLC patients. In vitro results showed that silencing CD147 increased the proliferation inhibitory effect of cisplatin to A549/DDP cells. In conclusion, our study indicated that membranous CD147 expression is a predictive factor of the response to cisplatin-based chemotherapies, and the use of CD147-targeted therapeutic adjuvants might be considered in the treatment of advanced NSCLC patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD147,
http://linkedlifedata.com/resource/pubmed/chemical/BSG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxycytidine,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Vinblastine,
http://linkedlifedata.com/resource/pubmed/chemical/gemcitabine,
http://linkedlifedata.com/resource/pubmed/chemical/vinorelbine
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0028-2685
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
58
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
449-54
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| pubmed:meshHeading |
pubmed-meshheading:21745000-Adenocarcinoma,
pubmed-meshheading:21745000-Antigens, CD147,
pubmed-meshheading:21745000-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:21745000-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:21745000-Carcinoma, Squamous Cell,
pubmed-meshheading:21745000-Cell Line, Tumor,
pubmed-meshheading:21745000-Cell Membrane,
pubmed-meshheading:21745000-Cell Proliferation,
pubmed-meshheading:21745000-Cisplatin,
pubmed-meshheading:21745000-Deoxycytidine,
pubmed-meshheading:21745000-Drug Resistance, Neoplasm,
pubmed-meshheading:21745000-Female,
pubmed-meshheading:21745000-Humans,
pubmed-meshheading:21745000-Immunoenzyme Techniques,
pubmed-meshheading:21745000-Lung Neoplasms,
pubmed-meshheading:21745000-Male,
pubmed-meshheading:21745000-Middle Aged,
pubmed-meshheading:21745000-Paclitaxel,
pubmed-meshheading:21745000-Survival Rate,
pubmed-meshheading:21745000-Treatment Outcome,
pubmed-meshheading:21745000-Vinblastine
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| pubmed:year |
2011
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| pubmed:articleTitle |
Expression of CD147 in advanced non-small cell lung cancer correlated with cisplatin-based chemotherapy resistance.
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| pubmed:affiliation |
School of Life Sciences and Technology, Tongji Univesity, Shanghai 200092, China.
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| pubmed:publicationType |
Journal Article
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