Source:http://linkedlifedata.com/resource/pubmed/id/21744341
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-7-27
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| pubmed:abstractText |
We have previously reported that over-expression of a panel of 119 genes correlates with the metastatic potential of pancreatic carcinoma cells. We sought to identify and functionally characterize candidate tumour metastasis promoting genes among this library using a secondary phenotype-assisted screen. Here we report the discovery of the metastasis-promoting function of a hitherto not characterized gene located on chromosome 14 (ORF138), which we have named 'novel metastasis-promoting gene 1' (NVM-1). The NVM-1 transcript is extensively alternatively spliced, is expressed endogenously in a number of different tissues, and is strongly over-expressed at the protein level in a variety of human tumour types. Importantly, NVM-1 expression stimulates the migratory and invasive behaviour of tumour cells and promotes metastasis formation in experimental animals in vivo. Up-regulation of FMNL2 and MT1E and down-regulation of TIMP4 and MHC-I is observed as a consequence of NVM-1 expression. Together these data identify NVM-1 as a gene that is functionally involved in tumour metastasis, and suggest that NVM-1 may constitute a promising therapeutic target for inhibition of tumour metastasis.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1096-9896
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| pubmed:author |
pubmed-author:AbdollahiAmirA,
pubmed-author:CremersNataschaN,
pubmed-author:FritzmannJohannesJ,
pubmed-author:HuberPeter EPE,
pubmed-author:MinkSigrunS,
pubmed-author:MollJürgenJ,
pubmed-author:NovacNataliaN,
pubmed-author:PlaumannDianaD,
pubmed-author:RegiertThomasT,
pubmed-author:RothleyMelanieM,
pubmed-author:SchlagPeterP,
pubmed-author:SchreiberCarolineC,
pubmed-author:SchwagerChristianC,
pubmed-author:SleemanJonathan PJP,
pubmed-author:SteinUlrikeU,
pubmed-author:ThieleWilkoW
|
| pubmed:copyrightInfo |
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
225
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
96-105
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| pubmed:meshHeading |
pubmed-meshheading:21744341-Alternative Splicing,
pubmed-meshheading:21744341-Animals,
pubmed-meshheading:21744341-Chromosomes, Human, Pair 14,
pubmed-meshheading:21744341-Female,
pubmed-meshheading:21744341-Gene Expression Profiling,
pubmed-meshheading:21744341-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21744341-Gene Knockdown Techniques,
pubmed-meshheading:21744341-Gene Library,
pubmed-meshheading:21744341-Genes, Neoplasm,
pubmed-meshheading:21744341-Humans,
pubmed-meshheading:21744341-Male,
pubmed-meshheading:21744341-Mice,
pubmed-meshheading:21744341-Mice, SCID,
pubmed-meshheading:21744341-Neoplasm Invasiveness,
pubmed-meshheading:21744341-Neoplasm Metastasis,
pubmed-meshheading:21744341-Neoplasm Proteins,
pubmed-meshheading:21744341-Neoplasm Transplantation,
pubmed-meshheading:21744341-Neoplasms,
pubmed-meshheading:21744341-Phenotype
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Discovery of a novel tumour metastasis-promoting gene, NVM-1.
|
| pubmed:affiliation |
University of Heidelberg, Medical Faculty Mannheim, Germany; KIT Campus Nord, Institut für Toxikologie und Genetik, Karlsruhe, Germany. wilko.thiele@medma.uni-heidelberg.de
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|