Linked Life Data

21743437

Source:http://linkedlifedata.com/resource/pubmed/id/21743437

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2011-8-17
pubmed:abstractText
Protein ubiquitylation is a key process in the regulation of many cellular processes. The balance between the activity of ubiquitin ligases and that of proteases controls the level of ubiquitylation. In response to extracellular stimuli, stress-activated protein kinases (SAPK) modulate gene expression to maximize cell survival. In yeast, the Hog1 SAPK has a key role in reprogramming the gene expression pattern required for cell survival upon osmostress. Here, we show that the Ubp3 ubiquitin protease is a target for the Hog1 SAPK to modulate gene expression. ubp3 mutant cells are defective in expression of osmoresponsive genes. Hog1 interacts with and phosphorylates Ubp3 at serine 695, which is essential to determine the extent of transcriptional activation in response to osmostress. Furthermore, Ubp3 is recruited to osmoresponsive genes to modulate transcriptional initiation as well as elongation. Therefore, Ubp3 activity responds to external stimuli and is required for transcriptional activation upon osmostress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1460-2075
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3274-84
pubmed:meshHeading
pubmed-meshheading:21743437-Endopeptidases, pubmed-meshheading:21743437-Gene Deletion, pubmed-meshheading:21743437-Gene Expression Regulation, Fungal, pubmed-meshheading:21743437-MAP Kinase Signaling System, pubmed-meshheading:21743437-Mitogen-Activated Protein Kinases, pubmed-meshheading:21743437-Osmotic Pressure, pubmed-meshheading:21743437-Phosphorylation, pubmed-meshheading:21743437-Protein Processing, Post-Translational, pubmed-meshheading:21743437-RNA, Fungal, pubmed-meshheading:21743437-RNA, Messenger, pubmed-meshheading:21743437-RNA Polymerase II, pubmed-meshheading:21743437-Recombinant Fusion Proteins, pubmed-meshheading:21743437-Saccharomyces cerevisiae Proteins, pubmed-meshheading:21743437-Transcription, Genetic, pubmed-meshheading:21743437-Transcriptional Activation, pubmed-meshheading:21743437-Ubiquitination
pubmed:year
2011
pubmed:articleTitle
Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress.
pubmed:affiliation
Departament de Ciències Experimentals i de la Salut, Cell Signalling Unit, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't