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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-7-11
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pubmed:databankReference |
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pubmed:abstractText |
TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions. Pin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness. Furthermore, we identified a transcriptional signature associated with poor prognosis in breast cancer and, in a cohort of patients, Pin1 overexpression influenced the prognostic value of p53 mutation. These results define a Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1878-3686
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pubmed:author |
pubmed-author:CapaciValeriaV,
pubmed-author:CrookTimT,
pubmed-author:Del SalGianninoG,
pubmed-author:GirardiniJavier EJE,
pubmed-author:LeeJordanJ,
pubmed-author:LozanoGuillerminaG,
pubmed-author:ManoMiguelM,
pubmed-author:MarottaCarolinaC,
pubmed-author:MeansAnthony RAR,
pubmed-author:NapoliMarcoM,
pubmed-author:PiazzaSilvanoS,
pubmed-author:QuinlanPhilP,
pubmed-author:RadaelliEnricoE,
pubmed-author:RosatoAntonioA,
pubmed-author:RustighiAlessandraA,
pubmed-author:ScanzianiEugenioE,
pubmed-author:SchneiderClaudioC,
pubmed-author:ThompsonAlastairA
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-91
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pubmed:meshHeading |
pubmed-meshheading:21741598-Animals,
pubmed-meshheading:21741598-Breast Neoplasms,
pubmed-meshheading:21741598-Cell Line, Tumor,
pubmed-meshheading:21741598-Cell Movement,
pubmed-meshheading:21741598-Disease Models, Animal,
pubmed-meshheading:21741598-Female,
pubmed-meshheading:21741598-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21741598-Gene Knock-In Techniques,
pubmed-meshheading:21741598-Humans,
pubmed-meshheading:21741598-Mice,
pubmed-meshheading:21741598-Models, Biological,
pubmed-meshheading:21741598-Mutant Proteins,
pubmed-meshheading:21741598-Neoplasm Invasiveness,
pubmed-meshheading:21741598-Peptidylprolyl Isomerase,
pubmed-meshheading:21741598-Transcription, Genetic,
pubmed-meshheading:21741598-Treatment Outcome,
pubmed-meshheading:21741598-Tumor Suppressor Protein p53
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pubmed:year |
2011
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pubmed:articleTitle |
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
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pubmed:affiliation |
Laboratorio Nazionale CIB, Trieste, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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