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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-8-5
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pubmed:abstractText |
Human embryonic stem cells can form cardiomyocytes when cultured under differentiation conditions. Although the initiating step of mesoderm formation is well characterized, the subsequent steps that promote for cardiac lineages are poorly understood and limit the yield of cardiomyocytes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
360-4
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pubmed:meshHeading |
pubmed-meshheading:21737789-Cardiac Myosins,
pubmed-meshheading:21737789-Cell Differentiation,
pubmed-meshheading:21737789-Cell Line,
pubmed-meshheading:21737789-Dose-Response Relationship, Drug,
pubmed-meshheading:21737789-Drug Discovery,
pubmed-meshheading:21737789-Embryonic Stem Cells,
pubmed-meshheading:21737789-Gene Expression Profiling,
pubmed-meshheading:21737789-Gene Expression Regulation, Developmental,
pubmed-meshheading:21737789-Genes, Reporter,
pubmed-meshheading:21737789-High-Throughput Screening Assays,
pubmed-meshheading:21737789-Humans,
pubmed-meshheading:21737789-Luminescent Proteins,
pubmed-meshheading:21737789-Mesoderm,
pubmed-meshheading:21737789-Microscopy, Fluorescence,
pubmed-meshheading:21737789-Myocytes, Cardiac,
pubmed-meshheading:21737789-Myosin Heavy Chains,
pubmed-meshheading:21737789-Promoter Regions, Genetic,
pubmed-meshheading:21737789-Signal Transduction,
pubmed-meshheading:21737789-Small Molecule Libraries,
pubmed-meshheading:21737789-Time Factors,
pubmed-meshheading:21737789-Transfection,
pubmed-meshheading:21737789-Wnt Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm.
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pubmed:affiliation |
Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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