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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1979-4-25
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pubmed:abstractText |
1. Glycopeptides and glycolipids were isolated from normal cat liver and liver from a cat affected with GM1 gangliosidosis. 2. Bio-Gel P-6 chromatography of the crude glycopeptide fractions demonstrated three major peaks of hexose-containing compounds that were greatly increased in the mutant liver sample; these peaks contained oligosaccharides that comprised over 2% of the liver wet weight. 3. Two of the major pathological oligosaccharides, GP5 and GP6, were purified by chromatography on charcoal/Celite and Sephadex G-25. Oligosaccharides GP5 and GP6 had apparent mol.wts. of 1800 +/- 200 and 1350+/-200 respectively, and contained galactose, mannose and N-acetylglucosamine in molar proportions of 2.0:3.1:4.1 (GP5) and 1.0:2.2:2.7 (GP6). Periodate oxidation studies demonstrated the presence of galactose in a non-reducing terminal position. 4. The neutral glycolipid fraction from the mutant cat liver has a 1.3-fold increase in hexose content accompanied by an increased concentration of asialo-(ganglioside GM1). 5. There was a 2-fold increase of gangliosides in the mutant cat liver compared with normal cats. Ganglioside GM1 and a compound tentatively identified as N-glycolloyl-(ganglioside GM1) were the major glycolipids accumulated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-1255166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-13436486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-14066623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-14209687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-14304842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-14416360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4119597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4177458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4243740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4256384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4285851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4291317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4345063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4361826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4452623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4686954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4710562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-4935452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-5040871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-5118883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-5349599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-5502663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-5792840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-603649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-816677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-820170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-885137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/217359-972144
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
945-53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:217359-Animals,
pubmed-meshheading:217359-Carbohydrates,
pubmed-meshheading:217359-Cats,
pubmed-meshheading:217359-Chromatography, Gel,
pubmed-meshheading:217359-Chromatography, Thin Layer,
pubmed-meshheading:217359-Gangliosidoses,
pubmed-meshheading:217359-Glycolipids,
pubmed-meshheading:217359-Humans,
pubmed-meshheading:217359-Liver,
pubmed-meshheading:217359-Oligosaccharides,
pubmed-meshheading:217359-Periodic Acid
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pubmed:year |
1978
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pubmed:articleTitle |
Hepatic storage of oligosaccharides and glycolipids in a cat affected with GM1 gangliosidosis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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