Linked Life Data

21735817

Source:http://linkedlifedata.com/resource/pubmed/id/21735817

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-7-6
pubmed:abstractText
DNA methyltransferase 1 (DNMT1) is one of three enzymes independently coded in mammalian cells. It catalyses postreplicative synthesis of 5-methylcytosine in DNA. The aim of this modification is regulation of gene expression characteristic for the given organism. DNMT1 maintains methylation pattern by copying it from maternal to daughter stand. S-adenosylo-L-methionina is a donor of methyl group in his process. Disturbance in methylation level results in changes in cell differentiation and finally to tumor transformation. Hypermethylation of promotor or first exon of tumor suppression gene results in silencing of its transcription. While hypomethylation of regulatory sequence of protooncogene and retrotransposon make them transcriptionally active. DNMT1 as a key enzyme in maintaing of proper methylation pattern is a attractive target in anti-tumor therapy.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0032-5422
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24-32
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
[Cytosine methylation in DNA and its role in cancer therapy].
pubmed:affiliation
Instytut Chemii Bioorganicznej, Polska Akademia Nauk, ul. Noskowskiego 12/14, 61-704 Pozna?.
pubmed:publicationType
Journal Article, English Abstract, Review