Mechanisms that increase resistance to apoptosis help promote cellular transformation. Cancer cells have deregulated apoptotic pathways, where increased expression and stability of anti-apoptotic proteins Mcl-1 and Bcl-2 increases resistance to apoptosis. Pathways that increase the stability of proteins in cancer cells remain poorly understood.
Department of Internal Medicine, Charles Drew University of Medicine and Science, 3084 Hawkins Building, 1731 East 120th Street, Los Angeles, CA 90059, USA. shehlapervin@cdrewu.edu
