Linked Life Data

2173042

Source:http://linkedlifedata.com/resource/pubmed/id/2173042

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-12-7
pubmed:abstractText
In six experiments, rats were placed on a heated plate on two occasions (test and retest), and the latencies with which they licked their paws were taken as an index of their sensitivity to nociceptive stimulation. Experiment 1 provided evidence that rats were selectively analgesic on retest depending upon the intensity of the heat experienced on the initial test. Experiment 2 showed that this analgesia was recruited rapidly and was long-lasting, as it was observed when retest was scheduled as early as 0.2 and as late as 48 h after the initial exposure to the hot-plate. Experiment 3 documented a role for conditioning processes, as this analgesia was removed by an extinction-like procedure conducted between test and retest. Experiments 4 and 5 provided evidence for a non-opioid mechanism of pain control, because the analgesia was not diminished by the opioid antagonist, naloxone, nor by a history of morphine injections. These experiments also revealed that the analgesia observed on retest was enhanced and reduced when rats were given naloxone and morphine, respectively, on the initial test. Finally, Experiment 6 showed that the analgesia on retest summated with that produced by morphine. The results were taken to mean that the hot-plate assay for analgesia can itself activate endogenous mechanisms of pain control, and some speculations were offered as to how this occurred.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0272-4995
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-65
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Some effects of exposure to a heat stressor upon the rat's subsequent reactions to that stressor.
pubmed:affiliation
University of New South Wales, Sydney, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't