|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2011-7-4
|
|
pubmed:abstractText |
Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia. Accordingly, in this study, we investigated the way in which capsaicin-mediated TRPV1 modulation could attenuate damage in an experimental hypoxic-ischemic (HI) neonatal brain injury model. The Rice-Vannucci method was used in 10-day-old rat pups by performing unilateral carotid artery ligation followed by 2 h of hypoxia (8% O2 at 37°C). Capsaicin was administered intraperitoneally (0.2 mg/kg or 2.0 mg/kg) at 3 h pre-HI or 1 h post-HI. Post assessment included measurement of infarction volume at 24 and 72 h in addition to an assessment of the vascular dynamics of the middle cerebral artery (MCA) at 6 h post-HI. The results indicated that pre-treatment with capsaicin reduced infarction volume significantly with either low-dose or high-dose treatment. Pre-treatment also improved myogenic tone and decreased apoptotic changes in the distal MCA. We concluded that capsaicin pre-treatment may provide neurovascular protection against neonatal HI.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0065-1419
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
111
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
225-30
|
|
pubmed:meshHeading |
pubmed-meshheading:21725760-Analysis of Variance,
pubmed-meshheading:21725760-Animals,
pubmed-meshheading:21725760-Animals, Newborn,
pubmed-meshheading:21725760-Brain Infarction,
pubmed-meshheading:21725760-Capsaicin,
pubmed-meshheading:21725760-Disease Models, Animal,
pubmed-meshheading:21725760-Drug Administration Schedule,
pubmed-meshheading:21725760-Gene Expression Regulation,
pubmed-meshheading:21725760-Infarction, Middle Cerebral Artery,
pubmed-meshheading:21725760-Middle Cerebral Artery,
pubmed-meshheading:21725760-Neuroprotective Agents,
pubmed-meshheading:21725760-Phosphopyruvate Hydratase,
pubmed-meshheading:21725760-Rats,
pubmed-meshheading:21725760-TRPV Cation Channels,
pubmed-meshheading:21725760-Tetrazolium Salts,
pubmed-meshheading:21725760-Time Factors,
pubmed-meshheading:21725760-von Willebrand Factor
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxic-ischemic brain injury in rats.
|
|
pubmed:affiliation |
Department of Anesthesiology, Loma Linda Medical Center, Loma Linda, CA 92354, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
