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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-7-4
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pubmed:abstractText |
Chromosome 3p21 is an important locus harboring critical tumor suppressor genes (TSGs) implicated in the pathogenesis of multiple tumors including esophageal carcinoma (EC). Aberrant promoter methylation is a fundamental mechanism of inactivation of TSGs in cancer. RASSF1A, a candidate tumor suppressor gene, recently cloned from the lung tumor locus at 3p21.3, is frequently inactivated by hypermethylation of its promoter region in a number of malignancies. We undertook this study to investigate the methylation status of RASSF1A and its significance in esophageal squamous cell carcinoma (ESCC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1873-5487
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
182-8
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pubmed:meshHeading |
pubmed-meshheading:21722812-Adult,
pubmed-meshheading:21722812-Aged,
pubmed-meshheading:21722812-Carcinoma, Squamous Cell,
pubmed-meshheading:21722812-Cell Line, Tumor,
pubmed-meshheading:21722812-DNA Methylation,
pubmed-meshheading:21722812-Disease-Free Survival,
pubmed-meshheading:21722812-Esophageal Neoplasms,
pubmed-meshheading:21722812-Female,
pubmed-meshheading:21722812-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21722812-Genetic Association Studies,
pubmed-meshheading:21722812-Humans,
pubmed-meshheading:21722812-Male,
pubmed-meshheading:21722812-Middle Aged,
pubmed-meshheading:21722812-Neoplasm Staging,
pubmed-meshheading:21722812-Prognosis,
pubmed-meshheading:21722812-Promoter Regions, Genetic,
pubmed-meshheading:21722812-Transcription, Genetic,
pubmed-meshheading:21722812-Tumor Suppressor Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Hypermethylation-modulated downregulation of RASSF1A expression is associated with the progression of esophageal cancer.
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pubmed:affiliation |
Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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