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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-8-15
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pubmed:abstractText |
Traffic related particulate matter air pollution is a risk factor for cardiovascular events; however, the biological mechanisms are unclear. We hypothesize that diesel exhaust (DE) inhalation induces up-regulation of inducible nitric oxide synthase (iNOS), which is known to contribute to vascular dysfunction, progression of atherosclerosis and ultimately cardiovascular morbidity and mortality.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Amidines,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD36,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylamines,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/N-(3-(aminomethyl)benzyl)acetamidine,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Particulate Matter,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Vehicle Emissions
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1096-0333
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
255
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-92
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pubmed:meshHeading |
pubmed-meshheading:21722660-Amidines,
pubmed-meshheading:21722660-Animals,
pubmed-meshheading:21722660-Antigens, CD36,
pubmed-meshheading:21722660-Aorta, Thoracic,
pubmed-meshheading:21722660-Apolipoproteins E,
pubmed-meshheading:21722660-Atherosclerosis,
pubmed-meshheading:21722660-Benzylamines,
pubmed-meshheading:21722660-Enzyme Inhibitors,
pubmed-meshheading:21722660-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:21722660-Male,
pubmed-meshheading:21722660-Mice,
pubmed-meshheading:21722660-Mice, Knockout,
pubmed-meshheading:21722660-Myocardium,
pubmed-meshheading:21722660-NF-kappa B,
pubmed-meshheading:21722660-Nitric Oxide Synthase Type II,
pubmed-meshheading:21722660-Particulate Matter,
pubmed-meshheading:21722660-RNA, Messenger,
pubmed-meshheading:21722660-Tyrosine,
pubmed-meshheading:21722660-Up-Regulation,
pubmed-meshheading:21722660-Vasoconstriction,
pubmed-meshheading:21722660-Vehicle Emissions
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pubmed:year |
2011
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pubmed:articleTitle |
Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice.
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pubmed:affiliation |
Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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