rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1-2
|
pubmed:dateCreated |
1990-12-13
|
pubmed:abstractText |
The secondary structure of the synthetic signal peptide of cytochrome c oxidase subunit IV (coxIV-25) has been measured by circular dichroism spectroscopy in different lipid environments. CoxIV-25 is polymorphic in membranes. It forms an amphiphilic alpha-helix both in negatively charged lipid bilayers (up to 49% helix) and in detergent micelles (up to 42% helix). In association with bilayers of the zwitterionic lipid phosphatidylcholine, coxIV-25 takes an aperiodic, unidentified structure. CoxIV-25 is also partially alpha-helical in bilayers of cardiolipin, mitochondrial lipid extracts and mixtures of synthetic phosphatidylcholine and phosphatidylglycerol.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
272
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
29-33
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2172017-Amino Acid Sequence,
pubmed-meshheading:2172017-Animals,
pubmed-meshheading:2172017-Cardiolipins,
pubmed-meshheading:2172017-Cattle,
pubmed-meshheading:2172017-Circular Dichroism,
pubmed-meshheading:2172017-Electron Transport Complex IV,
pubmed-meshheading:2172017-Lipid Bilayers,
pubmed-meshheading:2172017-Membrane Lipids,
pubmed-meshheading:2172017-Mitochondria, Heart,
pubmed-meshheading:2172017-Molecular Sequence Data,
pubmed-meshheading:2172017-Phosphatidylcholines,
pubmed-meshheading:2172017-Phosphatidylglycerols,
pubmed-meshheading:2172017-Protein Conformation,
pubmed-meshheading:2172017-Protein Sorting Signals
|
pubmed:year |
1990
|
pubmed:articleTitle |
Secondary structure of a mitochondrial signal peptide in lipid bilayer membranes.
|
pubmed:affiliation |
Department of Biophysical Chemistry, University of Basel, Switzerland.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|