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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1990-12-13
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pubmed:abstractText |
The action of ATP/ADP-antiporter inhibitors upon the uncoupling effect of palmitate, detergents and 'classical' uncouplers has been studied. The uncoupling effect was estimated by stimulation of succinate oxidation and of H+ permeability of rat liver mitochondria in the presence of oligomycin. It is shown that carboxyatractylate (CAtr) and pyridoxal 5-phosphate (PLP) suppress the uncoupling induced by palmitate and the anionic detergents SDS and cholate, but do not affect that induced by the cationic detergents CTAB, by the non-ionic detergent Triton X-100, as well as by the 'classical' uncouplers FCCP and DNP. The results are discussed in terms of a concept assuming that the ATP/ADP-antiporter facilitates the electrophoretic export of hydrophobic anions from mitochondria.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anions,
http://linkedlifedata.com/resource/pubmed/chemical/Atractyloside,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonyl Cyanide...,
http://linkedlifedata.com/resource/pubmed/chemical/Cholic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Cholic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Detergents,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial ADP, ATP Translocases,
http://linkedlifedata.com/resource/pubmed/chemical/Oligomycins,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Protons,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridoxal Phosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Rotenone,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Dodecyl Sulfate,
http://linkedlifedata.com/resource/pubmed/chemical/Succinates,
http://linkedlifedata.com/resource/pubmed/chemical/Succinic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Uncoupling Agents,
http://linkedlifedata.com/resource/pubmed/chemical/carboxyatractyloside
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
272
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2172013-Animals,
pubmed-meshheading:2172013-Anions,
pubmed-meshheading:2172013-Atractyloside,
pubmed-meshheading:2172013-Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone,
pubmed-meshheading:2172013-Cholic Acid,
pubmed-meshheading:2172013-Cholic Acids,
pubmed-meshheading:2172013-Detergents,
pubmed-meshheading:2172013-Mitochondria, Liver,
pubmed-meshheading:2172013-Mitochondrial ADP, ATP Translocases,
pubmed-meshheading:2172013-Oligomycins,
pubmed-meshheading:2172013-Oxidation-Reduction,
pubmed-meshheading:2172013-Oxygen Consumption,
pubmed-meshheading:2172013-Palmitic Acid,
pubmed-meshheading:2172013-Palmitic Acids,
pubmed-meshheading:2172013-Permeability,
pubmed-meshheading:2172013-Protons,
pubmed-meshheading:2172013-Pyridoxal Phosphate,
pubmed-meshheading:2172013-Rats,
pubmed-meshheading:2172013-Rotenone,
pubmed-meshheading:2172013-Sodium Dodecyl Sulfate,
pubmed-meshheading:2172013-Succinates,
pubmed-meshheading:2172013-Succinic Acid,
pubmed-meshheading:2172013-Uncoupling Agents
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pubmed:year |
1990
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pubmed:articleTitle |
Inhibitors of the ATP/ADP antiporter suppress stimulation of mitochondrial respiration and H+ permeability by palmitate and anionic detergents.
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pubmed:affiliation |
Institute of Biological Physics, USSR Academy of Science, Pushchino, Moscow Region.
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pubmed:publicationType |
Journal Article
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