Linked Life Data

21719949

Source:http://linkedlifedata.com/resource/pubmed/id/21719949

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2011-7-4
pubmed:abstractText
Conventional kilovoltage (kV) x-ray-based dual-energy CT (DECT) imaging using two different x-ray energy spectra is sensitive to image noise and beam hardening effects. The purpose of this study was to evaluate the theoretical advantage of the DECT method for determining proton stopping power ratios (SPRs) using a combination of kV and megavoltage (MV) x-ray energies. We investigated three representative x-ray energy pairs: 100 and 140 kVp comprised the kV-kV pair, 100 kVp and 1 MV comprised the kV-MV pair, and two 1 MV x-ray beams-one with and one without external filtration-comprised the MV-MV pair. The SPRs of 34 human tissues were determined using the DECT method with these three x-ray energy pairs. Small perturbations were introduced into the CT numbers and x-ray spectra used for the DECT calculation to simulate the effects of random noise and beam hardening. An error propagation analysis was performed on the DECT calculation algorithm to investigate the propagation of CT number uncertainty to final SPR estimation and to suggest the best x-ray energy combination. We found that the DECT method using each of the three beam pairs achieved similar accuracy in determining the SPRs of human tissues in ideal conditions. However, when CT number uncertainties and artifacts such as imaging noise and beam hardening effects were considered, the kV-MV DECT improved the accuracy of SPR estimation substantially over the kV-kV or MV-MV DECT methods. Furthermore, our error propagation analysis showed that the combination of 100 kVp and 1 MV beams was close to the optimal selection when using the DECT method to determine SPRs. Overall, the kV-MV combination makes the DECT method more robust in resolving the effective atomic numbers for biological tissues than the traditional kV-kV DECT method.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1361-6560
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4499-515
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Does kV-MV dual-energy computed tomography have an advantage in determining proton stopping power ratios in patients?
pubmed:affiliation
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural