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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-6-30
pubmed:abstractText
Keyhole limpet haemocyanin (KLH) appears to be a promising protein carrier for tumor antigens in numerous cancer vaccine candidates. The humoral immune response to KLH was characterized at the single-cell level with ELISPOT combined with separations of cell populations according to their expression of homing receptors (HRs). The analysis of HR expressions is expected to reveal the targeting of the immune response in the body. Eight orally primed and four nonprimed volunteers received KLH-vaccine subcutaneously. Circulating KLH-specific plasmablasts were found in all volunteers, 60 KLH-specific plasmablasts/10(6) PBMC in the nonprimed and 136/10(6) in the primed group. The proportion of L-selectin(+) plasmablasts proved high and integrin ?(4)?(7) (+) low. KLH serving as protein carrier in several vaccines, the homing profile of KLH-specific response may be applicable to the cancer antigen parts in the same vaccines. The present data reflect a systemic homing profile, which appears advantageous for the targeting of immune response to cancer vaccines.
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1740-2530
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2011
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
614383
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines.
pubmed:affiliation
Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Aurora Hospital, Building 5, 3rd floor, P.O. Box 348, 00029 Helsinki, Finland. anu.kantele@hus.fi
pubmed:publicationType
Journal Article