| pubmed-article:21716722 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0152035 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0018802 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:21716722 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:21716722 | pubmed:dateCreated | 2011-6-30 | lld:pubmed |
| pubmed-article:21716722 | pubmed:abstractText | Autoantibodies targeting the ?(1)-adrenergic receptor (AAB-?(1)) display agonist-like effects, which may have a pathogenic role in the progression of heart failure. Here, we used the electrophysiological recordings to explore the effects of AAB-?(1)-positive serum from Chinese patients with heart failure on the activity of the peak transient outward potassium current (I(to)) and the end 50 ms steady-state potassium current (I(ss)) in mouse cardiac myocytes. We found that the AAB-?(1)-positive serum had no effect on the activity of I(to), but it produced a decrease in the currents of I(ss). A low concentration of positive serum (1/100) had a small inhibitory effect on I(ss). However, positive serum at 1?:?10, 1?:?20, and 1?:?50 significantly decreased I(ss). The concentration-dependence analysis showed that the EC(50) of AAB-?(1)-positive serum was 1/60.24 and its nH was 2.86. It indicated that the AAB-?(1) could inhibit I(ss) in mouse cardiomyocyte in a concentration-dependent manner. | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21716722 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21716722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21716722 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21716722 | pubmed:issn | 1740-2530 | lld:pubmed |
| pubmed-article:21716722 | pubmed:author | pubmed-author:ZhangYunY | lld:pubmed |
| pubmed-article:21716722 | pubmed:author | pubmed-author:XXX | lld:pubmed |
| pubmed-article:21716722 | pubmed:author | pubmed-author:ZhangWeiW | lld:pubmed |
| pubmed-article:21716722 | pubmed:author | pubmed-author:LiXiao-DongXD | lld:pubmed |
| pubmed-article:21716722 | pubmed:author | pubmed-author:WangYuan-yuan... | lld:pubmed |
| pubmed-article:21716722 | pubmed:author | pubmed-author:WangJian-chun... | lld:pubmed |
| pubmed-article:21716722 | pubmed:author | pubmed-author:MaZhi-YongZY | lld:pubmed |
| pubmed-article:21716722 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21716722 | pubmed:volume | 2011 | lld:pubmed |
| pubmed-article:21716722 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21716722 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21716722 | pubmed:pagination | 143517 | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:meshHeading | pubmed-meshheading:21716722... | lld:pubmed |
| pubmed-article:21716722 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21716722 | pubmed:articleTitle | Serum positive for the autoantibody against the ?(1)-adrenoceptor from Chinese patients with congestive heart failure decreases I(ss) in mouse cardiac myocytes. | lld:pubmed |
| pubmed-article:21716722 | pubmed:affiliation | Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan 250012, China. | lld:pubmed |
| pubmed-article:21716722 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21716722 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
