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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-6-30
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pubmed:abstractText |
Autoantibodies targeting the ?(1)-adrenergic receptor (AAB-?(1)) display agonist-like effects, which may have a pathogenic role in the progression of heart failure. Here, we used the electrophysiological recordings to explore the effects of AAB-?(1)-positive serum from Chinese patients with heart failure on the activity of the peak transient outward potassium current (I(to)) and the end 50 ms steady-state potassium current (I(ss)) in mouse cardiac myocytes. We found that the AAB-?(1)-positive serum had no effect on the activity of I(to), but it produced a decrease in the currents of I(ss). A low concentration of positive serum (1/100) had a small inhibitory effect on I(ss). However, positive serum at 1?:?10, 1?:?20, and 1?:?50 significantly decreased I(ss). The concentration-dependence analysis showed that the EC(50) of AAB-?(1)-positive serum was 1/60.24 and its nH was 2.86. It indicated that the AAB-?(1) could inhibit I(ss) in mouse cardiomyocyte in a concentration-dependent manner.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-10362496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-10544184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-10653829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-11216956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-11448139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-12039504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-12528926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-12618516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-12679135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-12733822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-15028372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-15146239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-15256368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-15639650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-15910408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-16889792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-1700798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-1865177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-2449194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-7629102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-7683693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-7971176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-8205690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-8222078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-8290574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-9011624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21716722-9950662
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1740-2530
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2011
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143517
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pubmed:meshHeading |
pubmed-meshheading:21716722-Action Potentials,
pubmed-meshheading:21716722-Animals,
pubmed-meshheading:21716722-Autoantibodies,
pubmed-meshheading:21716722-China,
pubmed-meshheading:21716722-Heart Failure,
pubmed-meshheading:21716722-Humans,
pubmed-meshheading:21716722-Male,
pubmed-meshheading:21716722-Mice,
pubmed-meshheading:21716722-Mice, Inbred Strains,
pubmed-meshheading:21716722-Myocytes, Cardiac,
pubmed-meshheading:21716722-Receptors, Adrenergic, beta-1
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pubmed:year |
2011
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pubmed:articleTitle |
Serum positive for the autoantibody against the ?(1)-adrenoceptor from Chinese patients with congestive heart failure decreases I(ss) in mouse cardiac myocytes.
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pubmed:affiliation |
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan 250012, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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