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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-8-1
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pubmed:abstractText |
Elevated triglyceride levels are a risk factor for cardiovascular disease. Angiopoietin-like protein 4 (Angptl4) is a metabolic factor that raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). In non-diabetic individuals, the ANGPTL4 coding variant E40K has been associated with lower plasma triglyceride levels while the T266M variant has been associated with more modest effects on triglyceride metabolism. The objective of this study was to determine whether ANGPTL4 E40K and T266M are associated with triglyceride levels in the setting of obesity and T2D, and whether modification of triglyceride levels by these genetic variants is altered by a lifestyle intervention designed to treat T2D.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
pubmed-author:BalasubramanyamAshokA,
pubmed-author:CooperJackie AJA,
pubmed-author:HugginsGordon SGS,
pubmed-author:Kelley-HedgepethAlysonA,
pubmed-author:KopinAlanA,
pubmed-author:Look AHEAD Study,
pubmed-author:McCaffreyJeanne MJM,
pubmed-author:MontefuscoMaria ClaudiaMC,
pubmed-author:NathanDavid MDM,
pubmed-author:PeterIngaI,
pubmed-author:PownallHenry JHJ,
pubmed-author:Smart-HalajkoMelissa CMC,
pubmed-author:TalmudPhilippa JPJ
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89
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pubmed:meshHeading |
pubmed-meshheading:21714923-Aged,
pubmed-meshheading:21714923-Alleles,
pubmed-meshheading:21714923-Amino Acid Substitution,
pubmed-meshheading:21714923-Angiopoietins,
pubmed-meshheading:21714923-Cardiovascular Diseases,
pubmed-meshheading:21714923-Diabetes Mellitus, Type 2,
pubmed-meshheading:21714923-European Continental Ancestry Group,
pubmed-meshheading:21714923-Female,
pubmed-meshheading:21714923-Genetic Variation,
pubmed-meshheading:21714923-Homozygote,
pubmed-meshheading:21714923-Humans,
pubmed-meshheading:21714923-Life Style,
pubmed-meshheading:21714923-Lipoproteins, HDL,
pubmed-meshheading:21714923-Male,
pubmed-meshheading:21714923-Middle Aged,
pubmed-meshheading:21714923-Obesity,
pubmed-meshheading:21714923-Overweight,
pubmed-meshheading:21714923-Polymorphism, Single Nucleotide,
pubmed-meshheading:21714923-Risk Factors,
pubmed-meshheading:21714923-Triglycerides,
pubmed-meshheading:21714923-United States
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pubmed:year |
2011
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pubmed:articleTitle |
ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial.
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pubmed:affiliation |
Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and UCL Medical School, London, UK. m.smart-halajko@qmul.ac.uk.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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