|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2011-6-29
|
|
pubmed:abstractText |
Previously, CD47 gene expression has been shown to increase during mandible development using a micro array technique. To determine the function of CD47 in osteoblasts, CD47 was silenced using siRNA in vitro. The TGF-?1 and phosphorylated-Smad2 levels and transcription factor genes related to bone metabolism increased dose-dependently with CD47 silencing. Furthermore, we determined the distribution of CD47 in mouse embryonic E13 and E15 in vivo. The CD47-positive cells were localized in Meckel's cartilage and antenatal mandibular bone. These results suggest that TGF-?1 signaling and mandible development might be regulated by CD47.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
D
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD47,
http://linkedlifedata.com/resource/pubmed/chemical/Cd47 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1880-4926
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
53
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
169-75
|
|
pubmed:meshHeading |
pubmed-meshheading:21712621-3T3 Cells,
pubmed-meshheading:21712621-Animals,
pubmed-meshheading:21712621-Antigens, CD47,
pubmed-meshheading:21712621-Blotting, Western,
pubmed-meshheading:21712621-Cartilage,
pubmed-meshheading:21712621-Cell Culture Techniques,
pubmed-meshheading:21712621-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:21712621-Gene Silencing,
pubmed-meshheading:21712621-Gestational Age,
pubmed-meshheading:21712621-Immunohistochemistry,
pubmed-meshheading:21712621-Mandible,
pubmed-meshheading:21712621-Mesoderm,
pubmed-meshheading:21712621-Mice,
pubmed-meshheading:21712621-Osteoblasts,
pubmed-meshheading:21712621-Polymerase Chain Reaction,
pubmed-meshheading:21712621-RNA, Small Interfering,
pubmed-meshheading:21712621-Signal Transduction,
pubmed-meshheading:21712621-Smad2 Protein,
pubmed-meshheading:21712621-Transcription Factors,
pubmed-meshheading:21712621-Transforming Growth Factor beta1
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
CD47 regulates the TGF-? signaling pathway in osteoblasts and is distributed in Meckel's cartilage.
|
|
pubmed:affiliation |
Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan. shimada-ki@dent.nihon-u.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
