|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0030288,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0185125,
umls-concept:C0598496,
umls-concept:C0699493,
umls-concept:C0999699,
umls-concept:C1099354,
umls-concept:C1280500,
umls-concept:C1413365,
umls-concept:C1704353
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|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2011-7-18
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|
pubmed:abstractText |
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cyclic AMP regulated chloride channel expressed in the apical plasma membrane of pancreatic duct cells where it plays an important role in fluid secretion. The purpose of this study was to elucidate the role of the CFTR chloride channel on ion and fluid secretion from the guinea-pig pancreas by manipulating the expression of CFTR by RNA interference or by luminal application of a CFTR selective activator, MPB91, in isolated cultured pancreatic ducts.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1090-2104
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
410
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
904-9
|
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pubmed:meshHeading |
pubmed-meshheading:21708133-Animals,
pubmed-meshheading:21708133-Aquaporin 1,
pubmed-meshheading:21708133-Body Fluids,
pubmed-meshheading:21708133-Cystic Fibrosis Transmembrane Conductance Regulator,
pubmed-meshheading:21708133-Female,
pubmed-meshheading:21708133-Gene Knockdown Techniques,
pubmed-meshheading:21708133-Gene Silencing,
pubmed-meshheading:21708133-Guinea Pigs,
pubmed-meshheading:21708133-Humans,
pubmed-meshheading:21708133-Pancreatic Ducts,
pubmed-meshheading:21708133-Quinolizines,
pubmed-meshheading:21708133-RNA, Small Interfering,
pubmed-meshheading:21708133-Sequence Analysis, DNA,
pubmed-meshheading:21708133-Sequence Analysis, Protein
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|
pubmed:year |
2011
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|
pubmed:articleTitle |
Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.
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|
pubmed:affiliation |
Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan. sko@med.nagoya-u.ac.jp
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
