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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1990-11-13
|
| pubmed:abstractText |
Chronic Supraventricular Tachycardia (SVT) can produce a dilated cardiomyopathy which has a poorly understood association with ventricular dysfunction in humans and animals. The purpose of this study was to produce a model of chronic SVT and dilated cardiomyopathy using swine, which have a cardiac anatomy similar to man. Eight pigs were implanted with chronic atrial catheters and a pacemaker, with four additional sham-operated pigs serving as controls. We examined ventricular function and morphology at baseline (120 +/- 3 bpm), pacing baseline (240 bpm), and at 1, 2 and 3 weeks of rapid atrial pacing (240 bpm). Ventricular ejection fractions fell significantly from baseline following 1 week (left: 38 +/- 3% vs baseline 61 +/- 1%; right: 31 +/- 5% vs baseline 56 +/- 1%; p less than 0.05) and deteriorated further by 3 weeks of SVT (left: 26 +/- 4%, right: 19 +/- 3%; p less than 0.05). Significant biventricular chamber dilation developed by 2 weeks of SVT (left: 50 +/- 5 cc vs paced baseline 27 +/- 2 cc; right: 67 +/- 6 cc vs paced baseline 28 +/- 3 cc; p less than 0.05) and continued to increase by week 3 of SVT (left: 66 +/- 11 cc; right: 78 +/- 8 cc; p less than 0.05). Five additional paced pigs, without chronic atrial catheters, were followed using echocardiography.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0023-6764
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
495-501
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2170749-Animals,
pubmed-meshheading:2170749-Blood Pressure,
pubmed-meshheading:2170749-Cardiac Pacing, Artificial,
pubmed-meshheading:2170749-Cardiomyopathy, Dilated,
pubmed-meshheading:2170749-Catheters, Indwelling,
pubmed-meshheading:2170749-Chronic Disease,
pubmed-meshheading:2170749-Disease Models, Animal,
pubmed-meshheading:2170749-Heart,
pubmed-meshheading:2170749-Stroke Volume,
pubmed-meshheading:2170749-Swine,
pubmed-meshheading:2170749-Tachycardia, Supraventricular,
pubmed-meshheading:2170749-Ventricular Function
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
The pig as a model of tachycardia and dilated cardiomyopathy.
|
| pubmed:affiliation |
Department of Surgery, Medical University of South Carolina, Charleston.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|