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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2011-7-18
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pubmed:abstractText |
Leucine-rich repeat and fibronectin type III domain-containing (LRFN) family proteins are thought to be neuronal-specific proteins that play essential roles in neurite outgrowth and synapse formation. Here, we focused on expression and function of LRFN4, the fourth member of the LRFN family, in non-neural tissues. We found that LRFN4 was expressed in a wide variety of cancer and leukemia cell lines. We also found that expression of LRFN4 in the monocytic cell line THP-1 and in primary monocytes was upregulated following macrophage differentiation. Furthermore, we demonstrated that LRFN4 signaling regulated both the transendothelial migration of THP-1 cells and the elongation of THP-1 cells via actin cytoskeleton reorganization. Our data indicate that LRFN4 signaling plays an important role in the migration of monocytes/macrophages.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-3468
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pubmed:author |
pubmed-author:HoriShunsukeS,
pubmed-author:ItohReikoR,
pubmed-author:KajikawaMasunoriM,
pubmed-author:KawakamiTakaoT,
pubmed-author:KohrokiJunyaJ,
pubmed-author:KonakaharaShuS,
pubmed-author:MasuhoYasuhikoY,
pubmed-author:MuraiKenkoK,
pubmed-author:NakaneTakuT,
pubmed-author:SaitouMakiM,
pubmed-author:ShinsakaAyaA
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pubmed:copyrightInfo |
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
585
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2377-84
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pubmed:meshHeading |
pubmed-meshheading:21704618-Actins,
pubmed-meshheading:21704618-Animals,
pubmed-meshheading:21704618-Cell Line, Tumor,
pubmed-meshheading:21704618-Cell Movement,
pubmed-meshheading:21704618-Cytoskeleton,
pubmed-meshheading:21704618-Humans,
pubmed-meshheading:21704618-Macrophages,
pubmed-meshheading:21704618-Membrane Glycoproteins,
pubmed-meshheading:21704618-Monocytes,
pubmed-meshheading:21704618-Nerve Tissue Proteins,
pubmed-meshheading:21704618-Proteins,
pubmed-meshheading:21704618-Signal Transduction,
pubmed-meshheading:21704618-Tetradecanoylphorbol Acetate,
pubmed-meshheading:21704618-Transendothelial and Transepithelial Migration
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pubmed:year |
2011
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pubmed:articleTitle |
A neuronal transmembrane protein LRFN4 induces monocyte/macrophage migration via actin cytoskeleton reorganization.
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pubmed:affiliation |
Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan. s-konaka@rs.noda.tus.ac.jp
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pubmed:publicationType |
Journal Article
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