21702955

Source:http://linkedlifedata.com/resource/pubmed/id/21702955

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0086982, umls-concept:C0162508, umls-concept:C0162638, umls-concept:C0332291, umls-concept:C1150587, umls-concept:C1155873, umls-concept:C1367731, umls-concept:C1515877, umls-concept:C1517806, umls-concept:C1705632, umls-concept:C1879547
pubmed:dateCreated	2011-8-1
pubmed:abstractText	Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer including B cell leukemia. However, other molecular targets of JSI-124 beyond the JAK/STAT3 pathway are not fully understood.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100967800
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1, http://linkedlifedata.com/resource/pubmed/chemical/Triterpenes, http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A, http://linkedlifedata.com/resource/pubmed/chemical/cucurbitacin I
pubmed:status	MEDLINE
pubmed:issn	1471-2407
pubmed:author	pubmed-author:GibsonSpencer BSB, pubmed-author:IshdorjGanchimegG, pubmed-author:JohnstonJames BJB
pubmed:issnType	Electronic
pubmed:volume	11
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	268
pubmed:meshHeading	pubmed-meshheading:21702955-Apoptosis, pubmed-meshheading:21702955-Burkitt Lymphoma, pubmed-meshheading:21702955-Cell Cycle, pubmed-meshheading:21702955-Cell Line, Tumor, pubmed-meshheading:21702955-Drug Screening Assays, Antitumor, pubmed-meshheading:21702955-Enzyme Activation, pubmed-meshheading:21702955-Gene Expression Regulation, Leukemic, pubmed-meshheading:21702955-Genes, jun, pubmed-meshheading:21702955-Humans, pubmed-meshheading:21702955-Leukemia, B-Cell, pubmed-meshheading:21702955-MAP Kinase Kinase 4, pubmed-meshheading:21702955-Neoplasm Proteins, pubmed-meshheading:21702955-Phosphorylation, pubmed-meshheading:21702955-Protein Binding, pubmed-meshheading:21702955-Protein Processing, Post-Translational, pubmed-meshheading:21702955-Proto-Oncogene Proteins c-jun, pubmed-meshheading:21702955-RNA, Small Interfering, pubmed-meshheading:21702955-RNA Interference, pubmed-meshheading:21702955-STAT3 Transcription Factor, pubmed-meshheading:21702955-Signal Transduction, pubmed-meshheading:21702955-Transcription, Genetic, pubmed-meshheading:21702955-Transcription Factor AP-1, pubmed-meshheading:21702955-Triterpenes, pubmed-meshheading:21702955-Vascular Endothelial Growth Factor A
pubmed:year	2011
pubmed:articleTitle	Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells.

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