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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1990-10-19
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pubmed:abstractText |
Rat brain microsomal Na+, K(+)-ATPase activity was inhibited significantly and rapidly by ginsenoside Rb1. The IC50 of Rb1 for Na+,K(+)-ATPase was 6.3 +/- 1.0 mumol/L. The inhibition was enhanced with increasing the concentration of Rb1 or decreasing that of Na+ and K+. Kinetic analysis revealed that ginsenoside was an uncompetitive inhibitor with respect to ATP. The inhibitory effect of Rg1 on rat brain microsomal Na+,K(+)-ATPase was much weaker than that of Rb1.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
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pubmed:issn |
0253-9756
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
10-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2169691-Animals,
pubmed-meshheading:2169691-Brain,
pubmed-meshheading:2169691-Ginsenosides,
pubmed-meshheading:2169691-Male,
pubmed-meshheading:2169691-Microsomes,
pubmed-meshheading:2169691-Panax,
pubmed-meshheading:2169691-Plants, Medicinal,
pubmed-meshheading:2169691-Rats,
pubmed-meshheading:2169691-Rats, Inbred Strains,
pubmed-meshheading:2169691-Saponins,
pubmed-meshheading:2169691-Sodium-Potassium-Exchanging ATPase
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pubmed:year |
1990
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pubmed:articleTitle |
Inhibitory effects of ginsenoside Rg1 and Rb1 on rat brain microsomal Na+,K(+)-ATPase activity.
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pubmed:affiliation |
Department of Pharmacology, Nanjing Medical College, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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