| pubmed-article:2169638 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C0700602 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C0439861 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C0024620 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C0061078 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C1696465 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2169638 | lifeskim:mentions | umls-concept:C2700400 | lld:lifeskim |
| pubmed-article:2169638 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2169638 | pubmed:dateCreated | 1990-10-23 | lld:pubmed |
| pubmed-article:2169638 | pubmed:abstractText | The cytostatic effects of essential fatty acid metabolic intermediates and of some prostaglandins and leukotrienes in vitro have been extensively documented. The essential fatty acids (EFAs) exhibit no side-effects when taken as a dietary supplement, even in large doses. Primary Liver Cancer (PLC) is a fatal disease in our area as it is always multifocal in nature. In vitro studies have shown a cytostatic effect of gamma-linolenic acid (GLA) on primary liver cancer cells. In a double-blind placebo controlled trial, using Evening Primrose Oil (as a source of GLA) as a dietary supplement in PLC patients, no statistically significant effect was observed on survival time or liver size. There was however a statistical significant beneficial effect on Gamma Glutamyl transferase values as a measure of liver function. No side-effects were observed. The large size of tumour and the low doses of GLA used in this trial probably explain the lack of significant effect on survival times. | lld:pubmed |
| pubmed-article:2169638 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2169638 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2169638 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2169638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2169638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2169638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2169638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2169638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2169638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2169638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2169638 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2169638 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2169638 | pubmed:issn | 0952-3278 | lld:pubmed |
| pubmed-article:2169638 | pubmed:author | pubmed-author:BooyensJJ | lld:pubmed |
| pubmed-article:2169638 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:2169638 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:2169638 | pubmed:author | pubmed-author:JoubertH FHF | lld:pubmed |
| pubmed-article:2169638 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2169638 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:2169638 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2169638 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2169638 | pubmed:pagination | 199-202 | lld:pubmed |
| pubmed-article:2169638 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
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| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:meshHeading | pubmed-meshheading:2169638-... | lld:pubmed |
| pubmed-article:2169638 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2169638 | pubmed:articleTitle | The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. | lld:pubmed |
| pubmed-article:2169638 | pubmed:affiliation | Medical University of Southern Africa, Department of Internal Medicine. | lld:pubmed |
| pubmed-article:2169638 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2169638 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2169638 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2169638 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:2169638 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2169638 | lld:pubmed |
