|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1990-10-26
|
|
pubmed:abstractText |
Receptors for angiotensin II (AII) and atrial natriuretic peptide (ANP) were characterized in a membrane fraction from resistance-type artery from human placentae. Placentae from normal pregnancies and pregnancies complicated by intrauterine growth retardation (IUGR) were studied. High- and low-affinity receptors for AII (dissociation equilibrium constant (Kd) 1.7 and 15.7 nmol/l respectively) and ANP (Kd 0.2 and 55.5 nmol/l respectively) were identified; these parameters were unchanged in IUGR, but there was a reduction in high-affinity receptor number by approximately 50% for AII and 80% for ANP in this condition. Both peptides may have a role in the regulation of fetoplacental blood flow. The alterations in IUGR are consistent with sustained activation of the fetal renin-angiotensin system and suggest altered vascular responsiveness to ANP.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-0795
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
126
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
341-7
|
|
pubmed:dateRevised |
2005-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:2169524-Angiotensin II,
pubmed-meshheading:2169524-Arteries,
pubmed-meshheading:2169524-Atrial Natriuretic Factor,
pubmed-meshheading:2169524-Female,
pubmed-meshheading:2169524-Fetal Growth Retardation,
pubmed-meshheading:2169524-Humans,
pubmed-meshheading:2169524-Placenta,
pubmed-meshheading:2169524-Pregnancy,
pubmed-meshheading:2169524-Radioligand Assay,
pubmed-meshheading:2169524-Receptors, Angiotensin,
pubmed-meshheading:2169524-Receptors, Atrial Natriuretic Factor,
pubmed-meshheading:2169524-Receptors, Cell Surface
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
Vascular angiotensin II and atrial natriuretic peptide receptors in normal and growth-retarded human placentae.
|
|
pubmed:affiliation |
Medical Research Council Blood Pressure Unit, Western Infirmary, Glasgow.
|
|
pubmed:publicationType |
Journal Article
|
