|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2011-8-10
|
|
pubmed:abstractText |
Aminocoumarin antibiotics are potent inhibitors of bacterial DNA gyrase. We investigated the inhibitory and antibacterial activity of naturally occurring aminocoumarin antibiotics and six structural analogues (novclobiocins) against DNA gyrase and DNA topoisomerase IV from Escherichia coli and Staphylococcus aureus as well as the effect of potassium and sodium glutamate on the activity of these enzymes.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1460-2091
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
66
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2061-9
|
|
pubmed:meshHeading |
pubmed-meshheading:21693461-Aminocoumarins,
pubmed-meshheading:21693461-Anti-Bacterial Agents,
pubmed-meshheading:21693461-Bacterial Proteins,
pubmed-meshheading:21693461-Cloning, Molecular,
pubmed-meshheading:21693461-DNA, Superhelical,
pubmed-meshheading:21693461-DNA Gyrase,
pubmed-meshheading:21693461-DNA Topoisomerase IV,
pubmed-meshheading:21693461-Escherichia coli,
pubmed-meshheading:21693461-Glutamates,
pubmed-meshheading:21693461-Microbial Sensitivity Tests,
pubmed-meshheading:21693461-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21693461-Sodium Glutamate,
pubmed-meshheading:21693461-Staphylococcus aureus,
pubmed-meshheading:21693461-Structure-Activity Relationship,
pubmed-meshheading:21693461-Topoisomerase Inhibitors
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.
|
|
pubmed:affiliation |
Pharmaceutical Biology, Pharmaceutical Institute, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
