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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-8-4
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pubmed:abstractText |
RanGTP, which is generated on chromosomes during mitosis, is required for microtubule spindle assembly. Due to its restricted spatial generation within the cell it has been suggested that RanGTP acts as a spatial cue to organize site-specific spindle assembly within the cell. However, the absence of a detectable sharp gradient of RanGTP in somatic cells has led to suggestions that it may only act as a spatial cue in large cells and that it may operate as a general activator of the mitotic cytosol in somatic cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1768-322X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
421-34
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pubmed:meshHeading |
pubmed-meshheading:21692748-Cell Cycle Proteins,
pubmed-meshheading:21692748-Cell Line,
pubmed-meshheading:21692748-Cell Membrane,
pubmed-meshheading:21692748-Chromosomes,
pubmed-meshheading:21692748-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:21692748-Humans,
pubmed-meshheading:21692748-Kinesin,
pubmed-meshheading:21692748-Microtubules,
pubmed-meshheading:21692748-Mitosis,
pubmed-meshheading:21692748-Mitotic Spindle Apparatus,
pubmed-meshheading:21692748-Nuclear Proteins,
pubmed-meshheading:21692748-Protein Transport,
pubmed-meshheading:21692748-ran GTP-Binding Protein
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pubmed:year |
2011
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pubmed:articleTitle |
The site of RanGTP generation can act as an organizational cue for mitotic microtubules.
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pubmed:affiliation |
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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