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pubmed-article:21689419pubmed:abstractTextXPC is involved in the nucleotide excision repair of DNA damaged by carcinogens known to cause bladder cancer. Individuals homozygous for the variant allele of XPC c.1496C > T (p.Ala499Val) were shown in a large pooled analysis to have an increased bladder cancer risk, and we found two 3'UTR variants, *611T > A and c.*618A > G, to be in strong linkage disequilibrium with c.1496T. Here we determined if these two 3'UTR variants can affect mRNA stability and assessed the impact of all three variants on mRNA and protein expression.lld:pubmed
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pubmed-article:21689419pubmed:articleTitleFunctional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.lld:pubmed
pubmed-article:21689419pubmed:affiliationSection of Experimental Oncology, Leeds Institute of Molecular Medicine, Leeds LS9 7TF, UK.lld:pubmed
pubmed-article:21689419pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21689419pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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