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rdf:type |
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lifeskim:mentions |
umls-concept:C0005684,
umls-concept:C0205214,
umls-concept:C0205245,
umls-concept:C0205419,
umls-concept:C0237881,
umls-concept:C0332285,
umls-concept:C0600600,
umls-concept:C0750502,
umls-concept:C1421540,
umls-concept:C1510438,
umls-concept:C1516213,
umls-concept:C2752147
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pubmed:dateCreated |
2011-7-25
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pubmed:abstractText |
XPC is involved in the nucleotide excision repair of DNA damaged by carcinogens known to cause bladder cancer. Individuals homozygous for the variant allele of XPC c.1496C > T (p.Ala499Val) were shown in a large pooled analysis to have an increased bladder cancer risk, and we found two 3'UTR variants, *611T > A and c.*618A > G, to be in strong linkage disequilibrium with c.1496T. Here we determined if these two 3'UTR variants can affect mRNA stability and assessed the impact of all three variants on mRNA and protein expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-10681431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-11900249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-14652276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-16378601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-16957781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-17164382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-17671797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-17855631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-19373277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-19706757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-8298653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21689419-9734359
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84
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pubmed:meshHeading |
pubmed-meshheading:21689419-3' Untranslated Regions,
pubmed-meshheading:21689419-Alleles,
pubmed-meshheading:21689419-Cell Line,
pubmed-meshheading:21689419-DNA-Binding Proteins,
pubmed-meshheading:21689419-Homozygote,
pubmed-meshheading:21689419-Humans,
pubmed-meshheading:21689419-Polymorphism, Single Nucleotide,
pubmed-meshheading:21689419-Protein Biosynthesis,
pubmed-meshheading:21689419-RNA, Messenger,
pubmed-meshheading:21689419-RNA Stability,
pubmed-meshheading:21689419-Risk Factors,
pubmed-meshheading:21689419-Transcription, Genetic,
pubmed-meshheading:21689419-Urinary Bladder Neoplasms
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pubmed:year |
2011
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pubmed:articleTitle |
Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.
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pubmed:affiliation |
Section of Experimental Oncology, Leeds Institute of Molecular Medicine, Leeds LS9 7TF, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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